Dried Plum Polyphenols Inhibit Osteoclastogenesis

JOURNAL: Calcified Tissue International(DOI 10.1007/s00223-008-9139-0).

AUTHORS: Bu SY, Lerner M, Stoecker BJ, Boldrin E, Brackett DJ, Lucas EA and Smith BJ.

This study investigated dried plum polyphenols’ effect on osteoclast differentiation and activity in cell cultures.  Results of this study, combined with results of the authors’ previous reports, suggest that the antiresorptive properties of dried plums observed in animal studies are in part mediated by polyphenols suppression of osteoclast differentiation and activity under normal, oxidative stress, and inflammatory conditions.