Dried Plum Polyphenols Attenuate Detrimental Effects on Osteoblast Function

JOURNAL: Journal of Nutritional Biochemistry DOI:10.1016/j.jnutbio.2007.11.012 Published online ahead of print May 20, 2008.

AUTHORS: Bu, S.Y., Hunt, T.S., and Smith, B.J.

This cell culture study investigated how dried plum polyphenols and different concentrations ((0, 2.5, 5, 10 and 20 μg/ml) might influence osteoblast activity and mineralized nodule formation under normal and inflammatory conditions. Polyphenol doses of 5, 10 and 20 μg/ml enhanced the production of compounds linked to bone formation and countered the detrimental effects of TNF-a addition.